Omeprazole:Uses, indication, contraindication and therapeutic interaction

Omeprazole is used to treat cases in which excessive amounts of acid are secreted in the stomach. It inhibits the action of some enzymes responsible for acid secretion, thus preventing acid production.

Omeprazole

Uses of omeprazole

Include the following: 

• Heartburn.
• Acute gastritis .
• Duodenitis.
• Esophagitis .
• peptic ulcer
• Zollinger Ellison Syndrome.
• Part of a combined treatment to eradicate Helicobacter pylori .

Instructions for taking omeprazole

How to eat:

• capsules.
• discs.
• suspended solution.
• powder.

Dosage:

The dose ranges from 20-40 milligrams per day.

Event start:

Within 30 - 210 minutes.

Effective time

24 hours.

feed:

There are no specific restrictions.

Storage and preservation:

It should be stored in an airtight container out of moisture and out of reach of children.

Forgetting a dose:

Take it as soon as you remember, but if your next dose is within two hours, you should take only one dose immediately and skip the next dose. Do not take two doses at the same time.

discontinuation of medication:

Do not stop taking the drug without medical advice, as symptoms may reappear.

overdose:

In the event of a significant overdose or in the event of the appearance of special symptoms, consult a doctor or emergency room immediately.

Warnings when taking omeprazole

During pregnancy:

Consult the doctor about the possibility of taking the drug.

Breast feeding:

It has not been proven that using medicine is safe for nursing mothers. It is not recommended to take it.

Babies 

It is not recommended for use by children under 12 years of age, except on the advice of a doctor.

Elderly:

There are no special problems.

Driving:

You should refrain from driving until the effect of the drug becomes clear, as it may cause blurring (blurring).

Use of long treatments

Surgery and anesthesia:

The surgeon or the anesthetist must be informed of the use of this medicine.

Side effects of omeprazole

Headache

Popularity of influence: common

Inform the doctor: In severe cases

Nausea

Popularity of influence: common

Inform the doctor: In severe cases

Rash

Frequency of effect: rare

Inform the doctor: In each case

stop taking the medicine

Heading to the hospital

Heat

Frequency of effect: rare

Inform the doctor: In each case

stop taking the medicine

Heading to the hospital

Diarrhea

Popularity of influence: common

Inform the doctor: In severe cases

Hair loss

Frequency of effect: rare

Inform the doctor: In severe cases

Liver enzyme defects

Frequency of effect: rare

Inform the doctor: In each case 

Find out what are the interactions of omeprazole with other medicines

Omeprazole drug interactions with diazepam

degree of interaction

Omeprazole increases diazepam levels and increases its sedative effect. The probability of this interaction is much greater in the elderly. There may be a need to reduce the dose of diazepam, or to consider giving another drug from the benzodiazepines family that does not interact with omeprazole, such as: Lorazepam or Oxazepam.

Omeprazole drug interactions with Phenytoin

degree of interaction

Omeprazole may increase the levels of phenytoin in the blood, and increase the possibility of its side effects. The risk is greater when it comes to high doses of omeprazole (40 mg per day and above). Inform the doctor if abnormal side effects appear, such as: blurring (blurring), changes in vision, changes in behavior, seizures, nausea or shortness of breath.

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Omeprazole drug interactions with clarithromycin

Degree of interaction

The simultaneous use of clarithromycin and omeprazole increases the concentration and efficacy of these two drugs. This combination is effective in treating Helicobacter pylori (H. pylori).

Montelukast drug interactions with omeprazole

degree of interaction

Concomitant use of these two medicines may cause an increase in the blood level of montelukastsodium. Be careful of the possibility of side effects. The doctor will also change the dose as needed.

clozapine drug interactions with omeprazole

degree of interaction

Omeprazole may lower the level and effect of clozapine. Caution should be exercised when combining these drugs and monitoring the patient's response to treatment, especially when adding/discontinuing treatment with omeprazole or when changing the dose of omeprazole.

Riluzole drug interactions with omeprazole

degree of interaction

In vitro studies have shown that omeprazole may inhibit the breakdown of riluzole in the liver, leading to an increase in its level in the blood and an increase in its effect. The clinical significance of this interaction is not yet known, however when these drugs are combined, the patient should be monitored for possible reduction in the effect of riluzole.

Modafinil drug interactions with omeprazole

degree of interaction

Modafinil increases the effect of omeprazole and its side effects. Therefore, the dose of omeprazole may need to be reduced when the two medicines are used together.

Fluvastatin interactions with omeprazole

degree of interaction

Omeprazole inhibits the breakdown of lovastatin in the liver, which leads to an increase in the level of lovastatin in the blood, and as a result, the risk of muscle aches and weakness increases. The combination of these drugs should be avoided.

Ambrisentan drug interactions with omeprazole

degree of interaction

Omeprazole inhibits the breakdown of ambrisentan, and as a result, the potential for side effects of ambrisentan is increased. It is recommended not to combine these drugs together.

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